| EREDIVISIE 2021-2022 | ||||
| 1º Fecha | ||||
| 13-ago-2021 | Deventer | Go Ahead Eagles | 0 | |
| Heerenveen | 1 | Halilovic | ||
| 14-ago-2021 | Waalwijk | Waalwijk | 1 | Kramer |
| AZ | 0 | |||
| 14-ago-2021 | Almelo | Heracles | 0 | |
| PSV | 2 | Bruma, Madueke | ||
| 14-ago-2021 | Sittard | Fortuna | 2 | Seuntjens, Lake |
| Twente | 1 | Van Wolfswinkel | ||
| 14-ago-2021 | Amsterdam | Ajax | 5 | Haller, Mazraoui, Van Rooij, Tadic (2) |
| NEC | 0 | |||
| 15-ago-2021 | Leeuwarden | Cambuur | 1 | Maulun |
| Groningen | 2 | El Messaoudi, Larsen | ||
| 15-ago-2021 | Zwolle | PEC | 0 | |
| Vitesse | 1 | Fredriksen | ||
| 15-ago-2021 | Utrecht | Utrecht | 4 | Maher, Ban der Maarel, Douvikas, Gustafson (P) |
| Sparta | 0 | |||
| 15-ago-2021 | Tilburg | Willem II | 0 | |
| Feyenoord | 4 | Linssen, Sinisterra, Til, Bannis | ||
| 2º Fecha | ||||
| 20-ago-2021 | Nijmegen | NEC | 2 | Akman, Okita |
| PEC | 0 | |||
| 21-ago-2021 | Heerenveen | Heerenveen | 3 | Veerman (2, 1P), Halilovic |
| Waalwijk | 2 | Odgaard, Van der Venne | ||
| 21-ago-2021 | Eindhoven | PSV | 4 | Propper, Zahavi, Madueke, Boscagli |
| Cambuur | 1 | Bangura | ||
| 21-ago-2021 | Rotterdam | Sparta | 1 | Vriends |
| Heracles | 1 | Burgzorg | ||
| 21-ago-2021 | Groningen | Groningen | 0 | |
| Utrecht | 0 | |||
| 22-ago-2021 | Enschede | Twente | 1 | Propper |
| Ajax | 1 | Haller | ||
| 22-ago-2021 | Rotterdam | Feyenoord | 2 | Linssen (2) |
| Go Ahead Eagles | 0 | |||
| 22-ago-2021 | Arnhem | Vitesse | 0 | |
| Willem II | 3 | Wriedt, Nunnely, Spieringhs | ||
| 2-dic-2021 | Alkmaar | AZ | 2 | Plavidis, Karlsson |
| Fortuna | 1 | Flemming | ||
| 3º Fecha | ||||
| 27-ago-2021 | Sittard | Fortuna | 2 | Baghdadi, Seuntjens |
| Waalwijk | 2 | Kramer (2) | ||
| 28-ago-2021 | Cambuur | Cambuur | 2 | Jacobs (2) |
| Twente | 0 | |||
| 28-ago-2021 | Deventer | Go Ahead Eagles | 2 | Bakker (P), Botos |
| Sparta | 0 | |||
| 28-ago-2021 | Eindhoven | PSV | 5 | Gakpo, El Hankouri (A), Andre Ramalho, Zahavi, Bruma |
| Groningen | 2 | Ngonge (2) | ||
| 28-ago-2021 | Tilburg | Willem II | 1 | Saglam |
| PEC | 0 | |||
| 29-ago-2021 | Utrecht | Utrecht | 3 | Janssen, Sylla, Gustafson (P) |
| Feyenoord | 1 | Sinisterra | ||
| 29-ago-2021 | Amsterdam | Ajax | 5 | Antony, Alvarez, Gravenberch, Hajek (A), Klaassen |
| Vitesse | 0 | |||
| 29-ago-2021 | Almelo | Heracles | 0 | |
| NEC | 1 | Akman | ||
| 29-ago-2021 | Heerenveen | Heerenveen | 1 | Veerman |
| AZ | 3 | Pavlidis, Witry, De Wit | ||
| 4º Fecha | ||||
| 11-sep-2021 | Enschede | Twente | 1 | Propper |
| Utrecht | 0 | |||
| 11-sep-2021 | Zwolle | PEC | 0 | |
| Ajax | 2 | Haller (2) | ||
| 11-sep-2021 | Cambuur | Cambuur | 5 | Boere (2), Tol, Jacobs, Kiss |
| Go Ahead Eagles | 2 | Brouwers, Cordoba | ||
| 11-sep-2021 | Alkmaar | AZ | 0 | |
| PSV | 3 | Boscagli, Vertessen, Doan | ||
| 12-sep-2021 | Nijmegen | NEC | 0 | |
| Willem II | 0 | |||
| 12-sep-2021 | Rotterdam | Sparta | 3 | Smeets, Thy, Emegha |
| Fortuna | 1 | Seuntjens | ||
| 12-sep-2021 | Groningen | Groningen | 1 | Ngonge |
| Heerenveen | 1 | Halilovic | ||
| 12-sep-2021 | Waalwijk | Waalwijk | 1 | Bakari |
| Vitesse | 2 | Doekhi, Gboho | ||
| 1-dic-2021 | Rotterdam | Feyenoord | 2 | Sinisterra (2) |
| Heracles | 1 | Bakis | ||
| 5º Fecha | ||||
| 17-sep-2021 | Rotterdam | Sparta | 1 | Mijnans |
| NEC | 1 | Okita | ||
| 18-sep-2021 | Heerenveen | Heerenveen | 1 | Veerman |
| Fortuna | 0 | |||
| 18-sep-2021 | Tilburg | Willem II | 2 | Wriedt, Saddiki |
| Groningen | 1 | Suslov | ||
| 18-sep-2021 | Amsterdam | Ajax | 9 | Timber, Berghuis, Mazraoui, David Neres (2), Tadic, Daramy, Haller, Danilo |
| Cambuur | 0 | |||
| 18-sep-2021 | Utrecht | Utrecht | 2 | Gustafson, Douvikas (P) |
| Waalwijk | 2 | Odgaard, Buttner | ||
| 19-sep-2021 | Deventer | Go Ahead Eagles | 1 | Botos |
| PEC | 0 | |||
| 19-sep-2021 | Eindhoven | PSV | 0 | |
| Feyenoord | 4 | Toornstra (2), Linssen, Dessers | ||
| 19-sep-2021 | Arnhem | Vitesse | 1 | Darfalou |
| Twente | 4 | Propper (2), Van Wolfswinkel (P), Vlap | ||
| 19-sep-2021 | Almelo | Heracles | 3 | Sierhuis, Burgzorg, Vloet |
| AZ | 2 | Gudmundsson, Reijnders | ||
| 6º Fecha | ||||
| 21-sep-2021 | Sittard | Fortuna | 0 | |
| Ajax | 5 | Berghuis, Mazraoui, Tadic, Kudus, Tagliafico | ||
| 21-sep-2021 | Waalwijk | Waalwijk | 1 | Meulensteen |
| Willem II | 2 | Wriedt, Kohlert | ||
| 22-sep-2021 | Deventer | Go Ahead Eagles | 1 | Cordoba |
| PSV | 2 | Gakpo, Van Ginkel | ||
| 22-sep-2021 | Nijmegen | NEC | 0 | |
| Utrecht | 3 | Ramselaar (2), Douvikas | ||
| 22-sep-2021 | Groningen | Groningen | 0 | |
| Vitesse | 1 | Gboho | ||
| 22-sep-2021 | Rotterdam | Feyenoord | 3 | Til (2), Linssen |
| Heerenveen | 1 | Veerman | ||
| 22-sep-2021 | Zwolle | PEC | 1 | Redan |
| Sparta | 1 | Van Crooij | ||
| 23-sep-2021 | Cambuur | Cambuur | 2 | Breij, Hoedemakers |
| Heracles | 1 | Balis | ||
| 23-sep-2021 | Enschede | Twente | 3 | Van Wolfswinkel, Rots, Limnios |
| AZ | 1 | Karlsson | ||
| 7º Fecha | ||||
| 25-sep-2021 | Tilburg | Willem II | 2 | Zahavi (A), Nunnely |
| PSV | 1 | Zahavi | ||
| 25-sep-2021 | Amsterdam | Ajax | 3 | Alvarez, Antony, Mazraoui |
| Groningen | 0 | |||
| 25-sep-2021 | Arnhem | Vitesse | 1 | Frederiksen |
| Fortuna | 1 | Seuntjens | ||
| 25-sep-2021 | Rotterdam | Feyenoord | 5 | Kokcu (P), Sinisterra, Til (2), Dessers |
| NEC | 3 | Mattson, Odenthal, Verdonk | ||
| 25-sep-2021 | Utrecht | Utrecht | 5 | Douvikas (P), Sylla, Ramselaar, Mahi, Janssen |
| PEC1 | 1 | Saymak | ||
| 26-sep-2021 | Rotterdam | Sparta | 0 | |
| Cambuur | 4 | Bangura, Kallon (2), Boere | ||
| 26-sep-2021 | Alkmaar | AZ | 5 | Karlsson (2, 1P), De Wit, Aboukhlal, Reijnders |
| Go Ahead Eagles | 0 | |||
| 26-sep-2021 | Heerenveen | Heerenveen | 2 | Propper (A), Veerman |
| Twente | 3 | Van Wolfswinkel (P), Rots, Van Beek (A) | ||
| 26-sep-2021 | Almelo | Heracles | 1 | Burgzorg |
| Waalwijk | 0 | |||
| 8º Fecha | ||||
| 1-oct-2021 | Groningen | Groningen | 1 | Ngonge |
| Twente | 1 | Ugalde | ||
| 2-oct-2021 | Waalwijk | Waalwijk | 1 | Buttner (P) |
| Go Ahead Eagles | 1 | Cordoba | ||
| 2-oct-2021 | Almelo | Heracles | 3 | Vloet (P), Burgzorg, Azzaoui |
| Willem II | 2 | Kohlert, Svensson | ||
| 2-oct-2021 | Zwolle | PEC1 | 0 | |
| Heerenveen | 1 | Van Polen (A) | ||
| 2-oct-2021 | Sittard | Fortuna | 1 | Seuntjens (P) |
| NEC | 3 | Okita, Taysan, Bruijn | ||
| 3-oct-2021 | Amsterdam | Ajax | 0 | |
| Utrecht | 1 | Warmerdam | ||
| 3-oct-2021 | Cambuur | Cambuur | 1 | Uldrikis |
| AZ | 3 | De Wit, Wijndal, Clasie | ||
| 3-oct-2021 | Arnhem | Vitesse | 2 | Openda (2) |
| Feyenoord | 1 | Til | ||
| 3-oct-2021 | Eindhoven | PSV | 2 | Sangare, Thomas |
| Sparta | 1 | Thy | ||
| 9º Fecha | ||||
| 16-oct-2021 | Rotterdam | Feyenoord | 2 | Toornstra, Til |
| Waalwijk | 2 | Odgaard, Anita | ||
| 16-oct-2021 | Heerenveen | Heerenveen | 0 | |
| Ajax | 2 | Haller, David Neres | ||
| 16-oct-2021 | Deventer | Go Ahead Eagles | 4 | Brouwers (2), Knoester (A), Deijl |
| Heracles | 2 | Vloet, Rente | ||
| 16-oct-2021 | Sittard | Fortuna | 1 | Cox |
| Cambuur | 0 | |||
| 16-oct-2021 | Eindhoven | PSV | 3 | Andre Ramalho, Gakpo, Boscagli |
| PEC | 1 | Redan | ||
| 17-oct-2021 | Alkmaar | AZ | 5 | Pavlidis, Karlsson, De Wit (2), Gudmundsson (P) |
| Utrecht | 1 | Timber | ||
| 17-oct-2021 | Nijmegen | NEC | 0 | |
| Vitesse | 1 | Frederiksen | ||
| 17-oct-2021 | Rotterdam | Sparta | 1 | Smeets |
| Groningen | 1 | Ngonge | ||
| 17-oct-2021 | Enschede | Twente | 1 | Limnios |
| Willem II | 1 | Nunnely | ||
| 10º Fecha | ||||
| 22-oct-2021 | Tilburg | Willem II | 1 | Kohlert |
| Fortuna | 1 | Noslin | ||
| 23-oct-2021 | Utrecht | Utrecht | 2 | Sylla, Van de Streek |
| Heerenveen | 1 | Janssen (A) | ||
| 23-oct-2021 | Zwolle | PEC | 1 | Van Polen (P) |
| Heracles | 0 | |||
| 23-oct-2021 | Waalwijk | Waalwijk | 1 | Kramer |
| Sparta | 0 | |||
| 24-oct-2021 | Enschede | Twente | 1 | Misidjan |
| NEC | 2 | Tavsan, Vet | ||
| 24-oct-2021 | Cambuur | Cambuur | 2 | Sambissa (2) |
| Feyenoord | 3 | Linssen, Aursnes, Malacia | ||
| 24-oct-2021 | Arnhem | Vitesse | 1 | Openda (P) |
| Go Ahead Eagles | 2 | Cordoba, Brouwers (P) | ||
| 24-oct-2021 | Amsterdam | Ajax | 5 | Berghuis, Haller, Antony, Klaassen, Tadic |
| PSV | 0 | |||
| 24-oct-2021 | Groningen | Groningen | 2 | Ngonge, De Leeuw |
| AZ | 0 | |||
| 11º Fecha | ||||
| 30-oct-2021 | Eindhoven | PSV | 5 | Vertessen (2), Zahavi, Carlos Vinicius |
| Twente | 2 | Vlap, Zerrouki | ||
| 30-oct-2021 | Almelo | Heracles | 0 | |
| Ajax | 0 | |||
| 30-oct-2021 | Heerenveen | Heerenveen | 1 | Van Ewijk |
| Vitesse | 2 | Openda (2) | ||
| 30-oct-2021 | Alkmaar | AZ | 3 | D. De Wit, Pavlidis (2) |
| PEC | 2 | M. De Wit (2) | ||
| 31-oct-2021 | Rotterdam | Sparta | 0 | |
| Feyenoord | 1 | Dessers | ||
| 31-oct-2021 | Nijmegen | NEC | 3 | Akman, Taysan, Okita |
| Groningen | 0 | |||
| 31-oct-2021 | Utrecht | Utrecht | 5 | Ranselaar (3), Mallahi, Van Overeem |
| Willem II | 1 | Wriedt | ||
| 31-oct-2021 | Waalwijk | Waalwijk | 0 | |
| Cambuur | 1 | Kallon | ||
| 31-oct-2021 | Deventer | Go Ahead Eagles | 4 | Brouwers, Cardona, Cordoba, Kramer |
| Fortuna | 3 | Seuntjens, Rienstra, Tekie | ||
| 12º Fecha | ||||
| 5-nov-2021 | Enschede | Twente | 1 | Hilgers |
| Heracles | 0 | |||
| 6-nov-2021 | Nijmegen | NEC | 1 | Akman |
| Heerenveen | 1 | Veerman | ||
| 6-nov-2021 | Tilburg | Willem II | 0 | |
| Sparta | 3 | Vriends (2), Emegha | ||
| 6-nov-2021 | Zwolle | PEC | 1 | Huiberts |
| Cambuur | 2 | Hoedemakers, Maulun | ||
| 7-nov-2021 | Groningen | Groningen | 1 | Larsen |
| Waalwijk | 1 | Kramer | ||
| 7-nov-2021 | Sittard | Fortuna | 1 | Andre Ramalho (A) |
| PSV | 4 | Doan, Bruma (2), Sangare | ||
| 7-nov-2021 | Arnhem | Vitesse | 2 | Frederiksen, Bazoer |
| Utrecht | 1 | Zagre | ||
| 7-nov-2021 | Rotterdam | Feyenoord | 1 | Dessers |
| AZ | 0 | |||
| 7-nov-2021 | Amsterdam | Ajax | 0 | |
| Go Ahead Eagles | 0 | |||
| 13º Fecha | ||||
| 20-nov-2021 | Eindhoven | PSV | 2 | Sangare, Bruma |
| Vitesse | 0 | |||
| 20-nov-2021 | Rotterdam | Sparta | 0 | |
| Twente | 1 | Van Wolfswinkel (P) | ||
| 20-nov-2021 | Alkmaar | AZ | 1 | Aboukhlal |
| NEC | 1 | Bruijn | ||
| 20-nov-2021 | Almelo | Heracles | 3 | Azzaoui (2), Sierhuis |
| Fortuna | 1 | Flemming | ||
| 21-nov-2021 | Deventer | Go Ahead Eagles | 0 | |
| Groningen | 1 | Larsen | ||
| 21-nov-2021 | Rotterdam | Feyenoord | 4 | Linssen (2), Sinisterra, Til |
| PEC | 0 | |||
| 21-nov-2021 | Heerenveen | Heerenveen | 2 | Stevanovic, Bakker |
| Willem II | 1 | Nunnely | ||
| 21-nov-2021 | Waalwijk | Waalwijk | 0 | |
| Ajax | 5 | Haller (2), Berghuis (2), Timber | ||
| 21-nov-2021 | Cambuur | Cambuur | 2 | Uldrikis, Jacobs |
| Utrecht | 1 | Sylla | ||
| 14º Fecha | ||||
| 26-nov-2021 | Nijmegen | NEC | 2 | Barreto, Akman |
| Cambuur | 3 | Jacobs, Uldrikis, Bangura | ||
| 27-nov-2021 | Sittard | Fortuna | 1 | Seuntjens |
| Groningen | 4 | Ngonge, Cox (A), Irandust, Larsen | ||
| 27-nov-2021 | Zwolle | PEC | 0 | |
| Waalwijk | 0 | |||
| 27-nov-2021 | Tilburg | Willem II | 0 | |
| Go Ahead Eagles | 1 | Lucassen | ||
| 28-nov-2021 | Rotterdam | Sparta | 0 | |
| Ajax | 1 | Tadic | ||
| 28-nov-2021 | Enschede | Twente | 0 | |
| Feyenoord | 0 | |||
| 28-nov-2021 | Utrecht | Utrecht | 1 | Knoester (A) |
| Heracles | 0 | |||
| 28-nov-2021 | Heerenveen | Heerenveen | 1 | Al Hajj |
| PSV | 1 | Carlos Vinicius | ||
| 28-nov-2021 | Arnhem | Vitesse | 0 | |
| AZ | 0 | |||
| 15º Fecha | ||||
| 2-dic-2021 | Amsterdam | Ajax | 5 | Antony (2), Martinez, Klassen, Danilo |
| Willem II | 0 | |||
| 3-dic-2021 | Groningen | Groningen | 1 | Van den Belt (A) |
| PEC | 1 | De Wit | ||
| 4-dic-2021 | Eindhoven | PSV | 4 | Gakpo, Andre Ramalho, Doan, Mwene |
| Utrecht | 1 | Van der Hoorn | ||
| 4-dic-2021 | Cambuur | Cambuur | 1 | Tol |
| Vitesse | 6 | Tronstad (2), Openda (2), Buitink, Frederiksen | ||
| 4-dic-2021 | Almelo | Heracles | 0 | |
| Heerenveen | 1 | Veerman | ||
| 5-dic-2021 | Waalwijk | Waalwijk | 2 | Odgaard, Kuijpers |
| NEC | 1 | Bruijn | ||
| 5-dic-2021 | Alkmaar | AZ | 3 | Karlsson (2, 1P), Pavlidis |
| Sparta | 1 | Auassar | ||
| 5-dic-2021 | Deventer | Go Ahead Eagles | 1 | Cordoba |
| Twente | 2 | Van Wolfswinkel, Zerrouki | ||
| 5-dic-2021 | Rotterdam | Feyenoord | 5 | Til, Linssen (2), Sinisterra, Jahanbakhsh |
| Fortuna | 0 | |||
| 16º Fecha | ||||
| 10-dic-2021 | Tilburg | Willem II | 1 | Roemeratoe |
| Cambuur | 3 | Ulkridis, Maulun (P), Paulissen | ||
| 11-dic-2021 | Utrecht | Utrecht | 0 | |
| Go Ahead Eagles | 0 | |||
| 11-dic-2021 | Heerenveen | Heerenveen | 0 | |
| Sparta | 0 | |||
| 11-dic-2021 | Zwolle | PEC | 0 | |
| Fortuna | 1 | Lonwijk | ||
| 12-dic-2021 | Enschede | Twente | 2 | Van Wolfswinkel, Vlap |
| Waalwijk | 1 | Odgaard | ||
| 12-dic-2021 | Groningen | Groningen | 1 | Larsen |
| Feyenoord | 1 | Senesi | ||
| 12-dic-2021 | Arnhem | Vitesse | 2 | Openda (2, 1P) |
| Heracles | 1 | Laursen | ||
| 12-dic-2021 | Amsterdam | Ajax | 1 | Haller |
| AZ | 2 | Pavlidis, Aboukhlal | ||
| 12-dic-2021 | Nijmegen | NEC | 1 | Mattsson |
| PSV | 2 | Vertessen, Carlos Vinicius | ||
| 17º Fecha | ||||
| 18-dic-2021 | Sittard | Fortuna | 2 | Cox, Flemming |
| Utrecht | 2 | Mahi, Van de Streek | ||
| 18-dic-2021 | Rotterdam | Sparta | 2 | Mijnans (2) |
| Vitesse | 2 | Frederiksen (2) | ||
| 18-dic-2021 | Alkmaar | AZ | 4 | De Wit, Wellenreuther (A), Gudmundsson (2) |
| Willem II | 1 | Kabangu | ||
| 18-dic-2021 | Almelo | Heracles | 4 | Basacikoglu, Laursen, Kiomourtzoglou, Kasanwirjo (A) |
| Groningen | 2 | Larsen, Postema | ||
| 18-dic-2021 | Zwolle | PEC | 1 | Lagsir |
| Twente | 3 | Limnios, Ugalde, Misidjan | ||
| 19-dic-2021 | Cambuur | Cambuur | 1 | Uldrikis |
| Heerenveen | 2 | Veerman (2, 1P) | ||
| 19-dic-2021 | Rotterdam | Feyenoord | 0 | |
| Ajax | 2 | Senesi (A), Tadic (P) | ||
| 19-dic-2021 | Deventer | Go Ahead Eagles | 0 | |
| NEC | 2 | Tavsan, Bruijn (P) | ||
| 19-dic-2021 | Waalwijk | Waalwijk | 1 | Odgaard |
| PSV | 4 | Vertessen (2), Gakpo (P), Mwene | ||
| 18º Fecha | ||||
| 21-dic-2021 | Arnehm | Vitesse | 1 | Openda |
| PEC | 0 | |||
| 21-dic-2021 | Alkmaar | AZ | 1 | Karlsson |
| Groningen | 0 | |||
| 22-dic-2021 | Heerenveen | Heerenveen | 0 | |
| Feyenoord | 3 | Til, Senesi, Linssen | ||
| 22-dic-2021 | Tilburg | Willem II | 0 | |
| NEC | 1 | Mattson | ||
| 22-dic-2021 | Almelo | Heracles | 1 | Kiomourtzoglou |
| Cambuur | 1 | Breij | ||
| 22-dic-2021 | Utrecht | Utrecht | 1 | Mahi |
| Twente | 1 | Van Wolfswinkel | ||
| 22-dic-2021 | Amsterdam | Ajax | 5 | Blind, Antony, Rensch, Haller (2, 1P) |
| Fortuna | 0 | |||
| 23-dic-2021 | Eindhoven | PSV | 2 | Mwene, Gakpo |
| Go Ahead Eagles | 0 | |||
| 23-dic-2021 | Rotterdam | Sparta | 1 | Van Crooij |
| Waalwijk | 1 | Odgaard | ||
| 19º Fecha | ||||
| 14-ene-2022 | Zwolle | PEC | 2 | Van den Belt (2) |
| Willem II | 0 | |||
| 15-ene-2022 | Nijmegen | NEC | 0 | |
| Heracles | 0 | |||
| 15-ene-2022 | Rotterdam | Feyenoord | 0 | |
| Vitesse | 1 | Openda | ||
| 15-ene-2022 | Enschede | Twente | 2 | Ugalde, Van Wolfswinkel |
| Heerenveen | 0 | |||
| 15-ene-2022 | Deventer | Go Ahead Eagles | 0 | |
| Waalwijk | 2 | Stokkers, Kramer | ||
| 16-ene-2022 | Utrecht | Utrecht | 0 | |
| Ajax | 3 | Antony, Brobbey (2) | ||
| 16-ene-2022 | Groningen | Groningen | 0 | |
| PSV | 1 | Gotze | ||
| 16-ene-2022 | Cambuur | Cambuur | 1 | Coremans (A) |
| Sparta | 1 | Dalmau | ||
| 16-ene-2022 | Sittard | Fortuna | 1 | Rienstra |
| AZ | 2 | Beukema, Sugawara | ||
| 20º Fecha | ||||
| 22-ene-2022 | Arhnem | Vitesse | 1 | Oroz |
| Groningen | 3 | Larsen, Dasa (A), Van Kaam | ||
| 22-ene-2022 | Alkmaar | AZ | 0 | |
| Cambuur | 0 | |||
| 22-ene-2022 | Heerenveen | Heerenveen | 0 | |
| PEC | 1 | Van Polen (P) | ||
| 22-ene-2022 | Tillburg | Willem II | 0 | |
| Twente | 1 | Sadilek | ||
| 23-ene-2022 | Nijmegen | NEC | 1 | Schone |
| Feyenoord | 4 | Kokcu (2, 1P), Jahanbakhsh, Til | ||
| 23-ene-2022 | Almelo | Heracles | 1 | Sierhuis |
| Go Ahead Eagles | 1 | Lidberg | ||
| 23-ene-2022 | Eindhoven | PSV | 1 | Gotze |
| Ajax | 2 | Brobbey, Mazraoui | ||
| 23-ene-2022 | Rotterdam | Sparta | 0 | |
| Utrecht | 3 | Douvikas, Mahi, Coremans (A) | ||
| 23-ene-2022 | Waalwijk | Waalwijk | 2 | Gaari, Kramer |
| Fortuna | 1 | Seuntjens (P) | ||
| 21º Fecha | ||||
| 5-feb-2022 | Utrecht | Utrecht | 3 | Douvikas (2), Veerman |
| Cambuur | 2 | Schouten (2) | ||
| 5-feb-2022 | Sittard | Fortuna | 2 | Flemming (2) |
| Heerenveen | 0 | |||
| 5-feb-2022 | Zwolle | PEC | 1 | Redan |
| NEC | 1 | Bruijn | ||
| 5-feb-2022 | Eindhoven | PSV | 1 | Obispo |
| AZ | 2 | Martins Indi, Karlsson | ||
| 5-feb-2022 | Enschede | Twente | 3 | Bosch, Van Wolfswinkel (2, 1P) |
| Vitesse | 0 | |||
| 6-feb-2022 | Rotterdam | Feyenoord | 4 | Kokcu, Jahanbakhsh, Til (2) |
| Sparta | 0 | |||
| 6-feb-2022 | Groningen | Groningen | 2 | Larsen (2) |
| Go Ahead Eagles | 1 | Botos | ||
| 6-feb-2022 | Tilburg | Willem II | 3 | Oosting (2), Hornkamp |
| Waalwijk | 1 | Kramer | ||
| 6-feb-2022 | Amsterdam | Ajax | 3 | Klaassen, Haller, Taylor |
| Heracles | 0 | |||
| 22º Fecha | ||||
| 11-feb-2022 | Almelo | Heracles | 1 | Sierhuis |
| Utrecht | 0 | |||
| 12-feb-2022 | Groningen | Groningen | 0 | |
| Fortuna | 1 | Siovas | ||
| 12-feb-2022 | Cambuur | Cambuur | 3 | Maulun (P), Lamprou (A), Sambissa |
| PEC | 4 | Darfalou, De Wit, Redan, Van Polen | ||
| 12-feb-2022 | Arnhem | Vitesse | 0 | |
| PSV | 5 | Zahavi, Mauro Junior, Gakpo, Carlos Vinicius, Doan | ||
| 13-feb-2022 | Deventer | Go Ahead Eagles | 1 | Brouwers |
| AZ | 4 | Beukema (2), Pavlidis (2) | ||
| 13-feb-2022 | Rotterdam | Sparta | 1 | Namli |
| Willem II | 0 | |||
| 13-feb-2022 | Waalwijk | Waalwijk | 0 | |
| Feyenoord | 2 | Kokcu, Hendrix | ||
| 13-feb-2022 | Heerenveen | Heerenveen | 0 | |
| NEC | 1 | Tavsan | ||
| 13-feb-2022 | Amsterdam | Ajax | 5 | Klaassen, Haller (3), Propper (A) |
| Twente | 0 | |||
| 23º Fecha | ||||
| 19-feb-2022 | Nijmegen | NEC | 1 | Okita |
| Waalwijk | 1 | Van der Venne | ||
| 19-feb-2022 | Tilburg | Willem II | 0 | |
| Ajax | 1 | Timber | ||
| 19-feb-2022 | Alkmaar | AZ | 2 | Reijnders, Pavlidis |
| Heracles | 1 | Laursen | ||
| 20-feb-2022 | Zwolle | PEC | 1 | Nakayama |
| Groningen | 1 | Duarte | ||
| 20-feb-2022 | Enchede | Twente | 2 | Kramer (A), Brenet |
| Go Ahead Eagles | 2 | Lidberg, Cordoba | ||
| 20-feb-2022 | Rotterdam | Feyenoord | 3 | Sinisterra, Kokcu, Jahanbakhsh |
| Cambuur | 1 | Boere | ||
| 20-feb-2022 | Utrecht | Utrecht | 1 | Sylla |
| Vitesse | 1 | Doekhi | ||
| 20-feb-2022 | Eindhoven | PSV | 3 | Madueke, Gotze, Veerman |
| Heerenveen | 1 | Halilovic | ||
| 16-abr-2022 | Sittard | Fortuna | 3 | Seuntjens, Gladon (2) |
| Sparta | 0 | |||
| 24º Fecha | ||||
| 25-feb-2022 | Waalwijk | Waalwijk | 1 | Odgaard |
| Twente | 2 | Van Wolfswinkel, Limnios | ||
| 26-feb-2022 | Almelo | Heracles | 2 | De la Torre, Bakis |
| PEC | 0 | |||
| 26-feb-2022 | Groningen | Groningen | 1 | Meijer |
| Willem II | 0 | |||
| 26-feb-2022 | Cambuur | Cambuur | 2 | Boere (2) |
| Fortuna | 1 | Duarte | ||
| 27-feb-2022 | Alkmaar | AZ | 2 | Karlsson (2P) |
| Feyenoord | 1 | Geertruida | ||
| 27-feb-2022 | Arnehm | Vitesse | 4 | Doekhi, Oroz (2), Buitnik |
| NEC | 1 | Duelund | ||
| 27-feb-2022 | Rotterdam | Sparta | 1 | Thy |
| PSV | 2 | Mauro Junior, Doan | ||
| 27-feb-2022 | Deventer | Go Ahead Eagles | 2 | Cordoba, Rommens |
| Ajax | 1 | Berghuis | ||
| 27-feb-2022 | Heerenveen | Heerenveen | 1 | Van Hooijdonk (P) |
| Utrecht | 2 | Ramselaar, Van der Hoorn | ||
| 25º Fecha | ||||
| 5-mar-2022 | Tilburg | Willem II | 0 | |
| Heerenveen | 0 | |||
| 5-mar-2022 | Deventer | Go Ahead Eagles | 1 | Brouwers |
| Utrecht | 1 | Sylla | ||
| 5-mar-2022 | Rotterdam | Feyenoord | 1 | Dessers |
| Groningen | 1 | De Leeuw | ||
| 6-mar-2022 | Eindhoven | PSV | 3 | Veerman, Zahavi, Gakpo |
| Heracles | 1 | Armenteros | ||
| 6-mar-2022 | Enschede | Twente | 1 | Propper |
| Cambuur | 0 | |||
| 6-mar-2022 | Amsterdam | Ajax | 3 | Haller (2), Tadic (P) |
| Waalwijk | 2 | Kramer, Van der Venne | ||
| 6-mar-2022 | Nijmegen | NEC | 1 | Guth |
| AZ | 3 | Karlsson (2), Evjen | ||
| 6-mar-2022 | Sittard | Fortuna | 0 | |
| PEC | 1 | Darfalou | ||
| 19-abr-2022 | Arnhem | Vitesse | 0 | |
| Sparta | 1 | Dalmau | ||
| 26º Fecha | ||||
| 11-mar-2022 | Cambuur | Cambuur | 2 | Kallon, Joosten |
| Ajax | 3 | Tadic, Haller, Gravenberch | ||
| 12-mar-2022 | Rotterdam | Sparta | 1 | Auassar |
| Go Ahead Eagles | 0 | |||
| 12-mar-2022 | Groningen | Groningen | 4 | De Leeuw, Larsen, Postema (2) |
| NEC | 3 | Akman, Schone, Mattson | ||
| 12-mar-2022 | Waalwijk | Waalwijk | 0 | |
| Heerenveen | 0 | |||
| 13-mar-2022 | Sittard | Fortuna | 1 | Flemming |
| Willem II | 0 | |||
| 13-mar-2022 | Utrecht | Utrecht | 0 | |
| PSV | 1 | Zahavi | ||
| 13-mar-2022 | Almelo | Heracles | 0 | |
| Vitesse | 0 | |||
| 13-mar-2022 | Zwolle | PEC | 1 | Van Polen |
| Feyenoord | 2 | Sinisterra, Dessers | ||
| 13-mar-2022 | Alkmaar | AZ | 0 | |
| Twente | 1 | Brenet | ||
| 27º Fecha | ||||
| 18-mar-2022 | Heerenveen | Heerenveen | 2 | Sarr, Bakker |
| Heracles | 0 | |||
| 19-mar-2022 | Deventer | Go Ahead Eagles | 3 | Kramer, Brouwers, Deijl |
| Cambuur | 0 | |||
| 19-mar-2022 | Enschede | Twente | 1 | Rots |
| PEC | 0 | |||
| 19-mar-2022 | Nijmegen | NEC | 0 | |
| Sparta | 0 | |||
| 20-mar-2022 | Utrecht | Utrecht | 1 | Ramselaar |
| Groningen | 3 | El Hankouri (P), De Leeuw, Larsen | ||
| 20-mar-2022 | Amsterdam | Ajax | 3 | Haller, Tadic, Antony |
| Feyenoord | 2 | Sinisterra, Til | ||
| 20-mar-2022 | Eindhoven | PSV | 5 | Max, Doan, Zahavi, Bruma, Carlos Vinicius |
| Fortuna | 0 | |||
| 20-mar-2022 | Arnhem | Vitesse | 1 | Openda |
| Waalwijk | 2 | Meulensteen, Buttner | ||
| 20-mar-2022 | Tilburg | Willem II | 2 | Nunnely, Kabangu |
| AZ | 2 | Indi, Aboukhlal | ||
| 28º Fecha | ||||
| 2-abr-2022 | Groningen | Groningen | 1 | Starnd Larsen |
| Ajax | 3 | Klaasen, Tadic (P), Berghuis | ||
| 2-abr-2022 | Enschede | Twente | 3 | Van Wolfswinkel (2), Vlap |
| PSV | 3 | Veerman, Gakpo, Boscagli | ||
| 2-abr-2022 | Alkmaar | AZ | 3 | Pavlidis, Ramussen (A), Karlsson (P) |
| Vitesse | 1 | Tronstad | ||
| 2-abr-2022 | Waalwijk | Waalwijk | 1 | Kramer |
| Utrecht | 1 | Timber | ||
| 2-abr-2022 | Rotterdam | Feyenoord | 2 | Sinisterra, Linssen |
| Willem II | 0 | |||
| 3-abr-2022 | Zwolle | PEC | 0 | |
| Go Ahead Eagles | 1 | Rommens | ||
| 3-abr-2022 | Sittard | Fortuna | 0 | |
| Heracles | 2 | Quagliata, Bakis | ||
| 3-abr-2022 | Rotterdam | Sparta | 1 | Van Crooij (P) |
| Heerenveen | 1 | Sarr | ||
| 3-abr-2022 | Cambuur | Cambuur | 1 | Paulissen |
| NEC | 2 | Okita, Vet | ||
| 29º Fecha | ||||
| 8-abr-2022 | Deventer | Go Ahead Eagles | 4 | Lidberg, Cordoba, Heil, Cardona |
| Willem II | 0 | |||
| 9-abr-2022 | Utrecht | Utrecht | 1 | Ramselaar |
| Fortuna | 1 | Flemming | ||
| 9-abr-2022 | Amsterdam | Ajax | 2 | Klaassen, Tadic (P) |
| Sparta | 1 | De Kamps | ||
| 9-abr-2022 | Nijmegen | NEC | 0 | |
| Twente | 2 | Misidjan, Limnios | ||
| 10-abr-2022 | Heerenveen | Heerenveen | 3 | Van Hooijdonk (2), Van Beek |
| Groningen | 1 | Kasanwirjo | ||
| 10-abr-2022 | Eindhoven | PSV | 2 | Veerman, Teze |
| Waalwijk | 0 | |||
| 10-abr-2022 | Arnhem | Vitesse | 1 | Openda |
| Cambuur | 0 | |||
| 10-abr-2022 | Almelo | Heracles | 1 | Bakis |
| Feyenoord | 4 | Kokcu, Nelson, Til, Walemark | ||
| 10-abr-2022 | Zwolle | PEC | 2 | Kastaneer, Redan |
| AZ | 1 | Pavlidis | ||
| 30º Fecha | ||||
| 22-abr-2022 | Enschede | Twente | 2 | Van Wolfswinkel, Vlap |
| Sparta | 0 | |||
| 23-abr-2022 | Nijmegen | NEC | 0 | |
| Ajax | 1 | Brobbey | ||
| 23-abr-2022 | Alkmaar | AZ | 2 | Karlsson, Reijnders |
| Heerenveen | 1 | Sarr | ||
| 23-abr-2022 | Waalwijk | Waalwijk | 0 | |
| PEC | 2 | Van den Belt, Van Polen (P) | ||
| 23-abr-2022 | Cambuur | Cambuur | 1 | Joosten |
| PSV | 2 | Zahavi, Gotze | ||
| 24-abr-2022 | Tillburg | Willem II | 1 | Hornkamp |
| Vitesse | 0 | |||
| 24-abr-2022 | Groningen | Groningen | 0 | |
| Heracles | 1 | Laursen | ||
| 24-abr-2022 | Rotterdam | Feyenoord | 2 | Van der Hoorn (A), Sinisterra |
| Utrecht | 1 | Van de Streck | ||
| 24-abr-2022 | Sittard | Fortuna | 1 | Flemming |
| Go Ahead Eagles | 0 | |||
| 31º Fecha | ||||
| 29-abr-2022 | Utrecht | Utrecht | 1 | Douvikas |
| NEC | 0 | |||
| 30-abr-2022 | Amsterdam | Ajax | 3 | Tadic, Klaassen (2) |
| PEC | 0 | |||
| 30-abr-2022 | Almelo | Heracles | 1 | Fadiga |
| Twente | 1 | Smal | ||
| 30-abr-2022 | Rotterdam | Sparta | 1 | Van Crooij |
| AZ | 1 | Pavlidis | ||
| 1-may-2022 | Heerenveen | Heerenveen | 3 | Tahiri, Van Hooijdonk, Van Aken |
| Cambuur | 3 | Uldrikis, Maulun (P), Paulissen | ||
| 1-may-2022 | Deventer | Go Ahead Eagles | 1 | Lidberg |
| Vitesse | 2 | Openda (2) | ||
| 1-may-2022 | Eindhoven | PSV | 4 | Doan, Gakpo, Zahavi, Dammers (A) |
| Willem II | 2 | Nunnely, Kabangu | ||
| 1-may-2022 | Sittard | Fortuna | 1 | Flemming |
| Feyenoord | 3 | Geertruida (2), Nelson | ||
| 1-may-2022 | Waalwijk | Waalwijk | 3 | Stokkers (2), Van der Venne |
| Groningen | 1 | Strand Larsen | ||
| 32º Fecha | ||||
| 6-may-2022 | Cambuur | Cambuur | 1 | Smit |
| Waalwijk | 1 | Schmidt (A) | ||
| 7-may-2022 | Enschede | Twente | 1 | Van Wolfswinkel |
| Fortuna | 2 | Flemming (2) | ||
| 7-may-2022 | Zwolle | PEC | 1 | Redan |
| Utrecht | 1 | Ter Avest | ||
| 7-may-2022 | Tillburg | Willem II | 2 | Dammers, Hornkamp |
| Heracles | 0 | |||
| 7-may-2022 | Groningen | Groningen | 1 | Meijer |
| Sparta | 2 | Verschueren, Thy | ||
| 8-may-2022 | Nijmegen | NEC | 1 | Cissoko |
| Go Ahead Eagles | 0 | |||
| 8-may-2022 | Alkmaar | AZ | 2 | Pavlidis, Evjen |
| Ajax | 2 | Brobbey, Alvarez | ||
| 8-may-2022 | Arnhem | Vitesse | 1 | Bero (P) |
| Heerenveen | 2 | Sarr (2) | ||
| 8-may-2022 | Rotterdam | Feyenoord | 2 | Dessers (2, 1P) |
| PSV | 2 | Gakpo (2) | ||
| 33º Fecha | ||||
| 11-may-2022 | Amsterdam | Ajax | 5 | Tagliafico, Berghuis, Haller (P), Brobbey, Alvarez |
| Heerenveen | 0 | |||
| 11-may-2022 | Cambuur | Cambuur | 1 | Sylla |
| Willem II | 1 | Kohn | ||
| 11-may-2022 | Sittard | Fortuna | 1 | Gladon (P) |
| Vitesse | 2 | Manhoef, Openda | ||
| 11-may-2022 | Deventer | Go Ahead Eagles | 0 | |
| Feyenoord | 1 | Linssen | ||
| 11-may-2022 | Eindhoven | PSWV | 3 | Doan, Gutierrez, Zahavi |
| NEC | 2 | Duelund, Okita (P) | ||
| 11-may-2022 | Waalwijk | Waalwijk | 2 | Kramer, Van der Venne |
| Heracles | 0 | |||
| 11-may-2022 | Rotterdam | Sparta | 2 | Auassar, Van Crooij |
| PEC | 0 | |||
| 11-may-2022 | Enschede | Twente | 3 | Cerny, Limnios (2) |
| Groningen | 0 | |||
| 11-may-2022 | Utrecht | Utrecht | 2 | Van de Streek, Douvikas |
| AZ | 2 | Pavlidis (2) | ||
| 34º Fecha | ||||
| 15-may-2022 | Alkmaar | AZ | 1 | De Wit |
| Waalwijk | 3 | Stokkers, Gaari, Kuijpers | ||
| 15-may-2022 | Rotterdam | Feyenoord | 1 | Dessers |
| Twente | 2 | Limnios, Smal | ||
| 15-may-2022 | Groningen | Groningen | 2 | Strand Larsen, Postema |
| Cambuur | 3 | Uldrikis, Hoedemakers, Kallon (P) | ||
| 15-may-2022 | Almelo | Heracles | 1 | Bakis |
| Sparta | 3 | Verschueren, Thy, Engels | ||
| 15-may-2022 | Heerenveen | Heerenveen | 3 | Van Hooijdonk (2), Musaba |
| Go Ahead Eagles | 1 | Mulenga | ||
| 15-may-2022 | Nijmegen | NEC | 0 | |
| Fortuna | 1 | Flemming | ||
| 15-may-2022 | Zwolle | PEC | 1 | Kastaneer |
| PSV | 2 | Bruma, Ledezma | ||
| 15-may-2022 | Arnhem | Vitesse | 2 | Openda (2) |
| Ajax | 2 | Brobbey, Alvarez | ||
| 15-may-2022 | Tillburg | Willem II | 3 | Hornkamp, Saddiki, Van Overeem (A) |
| Utrecht | 0 | |||
| Promocion | ||||
| Primera Fase | ||||
| 9-may-2022 | Doetinchem | De Graafschap | 1 | Gravenberch (P) |
| Eindhoven | 1 | Sleegers (P) | ||
| 13-may-2022 | Eindhoven | Eindhoven | 3 | Ogenia, Brym, Sleegers |
| De Graafschap | 1 | Kaandorp | ||
| 10-may-2022 | Breda | NAC | 1 | Maria |
| ADO den Haag | 2 | Steijn, Komljenovic | ||
| 14-may-2022 | Den Haag | ADO den Haag | 2 | Malone (A), Klas |
| NAC | 1 | Banzuzi | ||
| 10-may-2022 | Rotterdam | Excelsior | 2 | Goudmijn, Dallinga (P) |
| Roda | 2 | Vente, Marzo | ||
| 14-may-2022 | Kerkrade | Roda | 0 | |
| Excelsior | 2 | Driouech, Agrafiotis | ||
| 10-may-2022 | Breda | NAC | 1 | Maria |
| ADO den Haag | 2 | Steijn, Komljenovic | ||
| 14-may-2022 | Den Haag | ADO den Haag | 2 | Malone (A), Klas |
| NAC | 1 | Banzuzi | ||
| Segunda Fase | ||||
| 17-may-2022 | Den Haag | ADO den Haag | 2 | Klas, Verheydt |
| Eindhoven | 1 | Sleegers (P) | ||
| 21-may-2022 | Eindhoven | Eindhoven | 1 | Amevor |
| ADO den Haag | 2 | Verheydt, Seedorf (A) | ||
| 18-may-2022 | Rotterdam | Excelsior | 3 | Azarkan, Dallinga, Driouech |
| Heracles | 0 | |||
| 21-may-2022 | Almelo | Heracles | 1 | Bakis |
| Excelsior | 3 | Dallinga, Wieffer, Agrafiotis | ||
| FINAL | ||||
| 24-may-2022 | Rotterdam | Excelsior | 1 | Azarkan |
| ADO den Haag | 1 | Steijn | ||
| 29-may-2022 | Den Haag | ADO den Haag | 4(7) | Verheydt, Felipe Pires, Steijn, Komljenovic |
| Excelsior | 4(8) | Azarkan, Niemeijer, Dallinga, El Yaakoubi | ||
| Playoffs Liga Europa | ||||
| Semifinales | ||||
| 19-may-2022 | Heerenveen | Heerenveen | 3 | Van Hooijdonk, Sarr, Halilovic |
| AZ | 2 | Evjen, Pavlidis | ||
| 22-may-2022 | Alkmaar | AZ | 2 | De Wit, Aboukhlal |
| Heerenveen | 0 | |||
| 19-may-2022 | Utrecht | Utrecht | 3 | Janssen, Van de Streek, Gustafson (P) |
| Vitesse | 1 | Vroegh | ||
| 22-may-2022 | Arnhem | Vitesse | 3 | Manhoef, Tronstad, Fredriksen |
| Utrecht | 0 | |||
| FINAL | ||||
| 26-may-2022 | Arnhem | Vitesse | 2 | Buitink, Openda |
| AZ | 1 | Clasie | ||
| 29-may-2022 | Alkmaar | AZ | 6 | Pavlidis, Reijnders (2), De Wit, Karlsson (2) |
| Vitesse | 1 | Bazoer | ||