| MLS 2025 | |||||
| 1ª Semana | |||||
| 22-feb-2025 | Los Angeles | Los Angeles | 1 | Ebobisse | |
| Minnesota United | 0 | ||||
| 22-feb-2025 | Fort Lauderdale | Inter | 2 | Aviles, Segovia | |
| New York City | 2 | Ilenic, Martinez | |||
| 22-feb-2025 | Atlanta | Atlanta United | 3 | Latte Lath (2), Mosquera | |
| Impact | 2 | Saliba, Owusu | |||
| 22-feb-2025 | Cincinnati | Cincinnati | 1 | Denkey | |
| Red Bulls | 0 | ||||
| 22-feb-2025 | Columbus | Crew | 4 | Russel-Rowe, Teran (A), Rossi (2) | |
| Fire | 2 | Gutierrez (2) | |||
| 22-feb-2025 | Washington | DC United | 2 | Enow, Benteke | |
| Toronto | 2 | Osorio, Bernardeschi (P) | |||
| 22-feb-2025 | Orlando | Orlando City | 2 | Pasalic (2) | |
| Union | 4 | Baribo (2), Gazdag, Uhre | |||
| 22-feb-2025 | Austin | Austin | 1 | Bukari | |
| Sporting | 0 | ||||
| 22-feb-2025 | Houston | Dynamo | 1 | Bassi | |
| Dallas | 2 | Musa, Julio | |||
| 22-feb-2025 | Nashville | Nashville | 0 | ||
| Revolution | 0 | ||||
| 22-feb-2025 | Saint Louis | Saint Louis City | 0 | ||
| Rapids | 0 | ||||
| 23-feb-2025 | San Jose | Earthquakes | 4 | Ricketts, Rodrigues, Bouda, Vitor Costa | |
| Real Salt Lake | 0 | ||||
| 23-feb-2025 | Seattle | Sounders | 2 | Morris (2) | |
| Charlotte | 2 | Malanda, Gomez (A) | |||
| 23-feb-2025 | Portland | Timbers | 1 | Antony | |
| Whitecaps | 4 | Gauld, Vite, Adekugbe, Nelson | |||
| 23-feb-2025 | Carson | Galaxy | 0 | ||
| San Diego | 2 | Dreyer (2) | |||
| 2ª Semana | |||||
| 1-mar-2025 | Charlotte | Charlotte | 2 | Biel, Zaha | |
| Atlanta United | 0 | ||||
| 1-mar-2025 | Sandy | Real Salt Lake | 2 | Tolo (A), Ajago | |
| Sounders | 0 | ||||
| 1-mar-2025 | Foxborough | Revolution | 0 | ||
| Crew | 1 | Russel-Rowe | |||
| 1-mar-2025 | Harrison | Red Bulls | 2 | Sofo, Forsberg | |
| Nashville | 0 | ||||
| 1-mar-2025 | Orlando | Orlando City | 4 | Araujo, Freeman, Ojeda, Thorhallsson | |
| Toronto | 2 | Rosted, Flores | |||
| 1-mar-2025 | Chester | Union | 4 | Baribo (3), Damiani | |
| Cincinnati | 1 | Evander | |||
| 1-mar-2025 | Chicago | Fire | 2 | Cuypers (2) | |
| DC United | 2 | Benteke, Murrell | |||
| 1-mar-2025 | Kansas City | Sporting | 1 | Joveljic (P) | |
| Earthquakes | 2 | Arango, Martinez | |||
| 1-mar-2025 | Saint Paul | Minnesota United | 1 | Yeboah | |
| Impact | 0 | ||||
| 1-mar-2025 | Commerce City | Rapids | 3 | Rosenberry, Navarro (2) | |
| Dallas | 3 | Pedrinho, Acosta, Musa | |||
| 2-mar-2025 | Los Angeles | Los Angeles | 1 | Hollingshead | |
| New York City | 0 | ||||
| 2-mar-2025 | Portland | Timbers | 1 | David Costa | |
| Austin | 0 | ||||
| 2-mar-2025 | Vancouver | Whitecaps | 2 | Adekugbe, White | |
| Galaxy | 1 | Gabriel Pec | |||
| 2-mar-2025 | San Diego | San Diego | 0 | ||
| Saint Louis City | 0 | ||||
| 2-mar-2025 | Dynamo | Houston | 1 | Lodeiro | |
| Inter | 4 | Segovia (2), Allende, Suarez | |||
| 3ª Semana | |||||
| 8-mar-2025 | Columbus | Crew | 0 | ||
| Dynamo | 0 | ||||
| 8-mar-2025 | Seattle | Sounders | 5 | Kossa-Rienzi, Rothrock, Morris, Roldan, Rusnak | |
| Los Angeles | 2 | Ordaz, Martinez | |||
| 8-mar-2025 | Atlanta | Atlantya United | 0 | ||
| Red Bulls | 0 | ||||
| 8-mar-2025 | Cincinnati | Cincinnati | 2 | Denkey (P), Kubo | |
| Toronto | 0 | ||||
| 8-mar-2025 | Washington | DC United | 2 | Benteke (P), Kijima | |
| Sporting | 1 | Thommy | |||
| 8-mar-2025 | Foxborough | Revolution | 0 | ||
| Union | 2 | Feingold (A), Lukic | |||
| 8-mar-2025 | Bronx | New York City | 2 | Martinez, Wolf | |
| Orlando City | 1 | Muriel | |||
| 8-mar-2025 | Austin | Austin | 0 | ||
| Rapids | 1 | Navarro | |||
| 8-mar-2025 | Frisco | Dallas | 1 | Farrington | |
| Fire | 3 | Gutman, Barroso, Cuypers (P) | |||
| 8-mar-2025 | Nashville | Nashville | 2 | Najar, Qasem | |
| Timbers | 0 | ||||
| 8-mar-2025 | Sandy | Real Salt Lake | 1 | Piol | |
| San Diego | 3 | Negri, Dreyer, Ingvartsen | |||
| 8-mar-2025 | Vancouver | Whitecaps | 2 | Laborda, Johnson | |
| Impact | 0 | ||||
| 9-mar-2025 | San Jose | Earthquakes | 0 | ||
| Minnesota United | 1 | Yeboah | |||
| 9-mar-2025 | Fort Lauderdale | Inter | 1 | Allende | |
| Charlotte | 0 | ||||
| 9-mar-2025 | Carson | Galaxy | 0 | ||
| Saint Louis City | 3 | Teuchert, Hartel, Becher | |||
| 4ª Semana | |||||
| 15-mar-2025 | Harrison | Red Bulls | 2 | Choupo-Moting (P), Gjengaar | |
| Orlando City | 2 | Ojeda, Pasalic | |||
| 15-mar-2025 | Toronto | Toronto | 1 | Kerr | |
| Fire | 2 | Gutman, Cuypers | |||
| 15-mar-2025 | Los Angeles | Los Angeles | 0 | ||
| Austin | 1 | Guilherme Brito | |||
| 15-mar-2025 | Charlotte | Charlotte | 2 | Abada, Agyemang | |
| Cincinnati | 0 | ||||
| 15-mar-2025 | Washington | DC United | 0 | ||
| Impact | 0 | ||||
| 15-mar-2025 | Bronx | New York City | 2 | Fernandez, Martinez | |
| Revolution | 1 | Thiago Martins (A) | |||
| 15-mar-2025 | Kansas City | Sporting | 3 | Salloi, Duggan (A), Joveljic | |
| Minnesota United | 3 | Dotson, Oluwaseyi (2) | |||
| 15-mar-2025 | Frisco | Dallas | 0 | ||
| Whitecaps | 1 | Blackmon | |||
| 15-mar-2025 | Houston | Dynamo | 1 | Ponce | |
| Real Salt Lake | 2 | Diogo Goncalves, Luna | |||
| 15-mar-2025 | Saint Louis | Saint Louis City | 1 | Lowen | |
| Sounders | 0 | ||||
| 15-mar-2025 | San Diego | San Diego | 1 | Valakari | |
| Crew | 1 | Arfsten | |||
| 15-mar-2025 | San Jose | Earthquakes | 1 | Arango | |
| Rapids | 2 | Bassett, Harris | |||
| 16-mar-2025 | Chester | Union | 1 | Lukic | |
| Nashville | 3 | Surridge, Qasem, Mukhtar (P) | |||
| 16-mar-2025 | Portland | Timbers | 1 | Mora | |
| Galaxy | 1 | Ramirez | |||
| 16-mar-2025 | Atlanta | Atlanta United | 1 | Latte Lath | |
| Inter | 2 | Messi, Picault | |||
| 5ª Semana | |||||
| 22-mar-2025 | Cincinnati | Cincinnati | 2 | Evander (2) | |
| Atlanta United | 2 | Latte Lath, Powell (A) | |||
| 22-mar-2025 | Saint Paul | Mionnesota United | 2 | Yeboah (2, 1P) | |
| Galaxy | 2 | Ramirez, Garces | |||
| 22-mar-2025 | Charlotte | Charlotte | 4 | Biel, Westwood, Bronico, Vargas | |
| Earthquakes | 1 | Arango (P) | |||
| 22-mar-2025 | Columbus | Crew | 0 | ||
| New York City | 0 | ||||
| 22-mar-2025 | Harrison | Red Bulls | 2 | Forsberg (2, 1P) | |
| Toronto | 1 | Kerr | |||
| 22-mar-2025 | Orlando | Orlando City | 4 | Muriel, Ojeda, Freeman, Pasalic | |
| DC United | 1 | MacNaughton | |||
| 22-mar-2025 | Chester | Union | 1 | Glavinovich | |
| Saint Louis City | 0 | ||||
| 22-mar-2025 | Kansas City | Sporting | 0 | ||
| Los Angeles | 2 | Martinez, Long | |||
| 22-mar-2025 | Nashville | Nashville | 3 | Muyl, Bauer, Perez | |
| Impact | 0 | ||||
| 22-mar-2025 | Commerce City | Rapids | 0 | ||
| Timbers | 3 | Atencio (A), Antony, Kelsy | |||
| 22-mar-2025 | Sandy | Real Salt Lake | 0 | ||
| Dallas | 1 | Acosta | |||
| 22-mar-2025 | Seattle | Soundrs | 0 | ||
| Dynamo | 0 | ||||
| 22-mar-2025 | Vancouver | Whitecaps | 1 | Rios | |
| Fire | 3 | Cuypers, Zinckernagel, Kouame | |||
| 23-mar-2025 | Austin | Austin | 2 | Vazquez, Gallagher | |
| San Diego | 1 | De la Torre | |||
| 6ª Semana | |||||
| 29-mar-2025 | Foxborough | Revolution | 2 | Gil (2, 1P) | |
| Red Bulls | 1 | Choupo-Motig | |||
| 29-mar-2025 | Toronto | Toronto | 0 | ||
| Whitecaps | 0 | ||||
| 29-mar-2025 | Commerce City | Rapids | 2 | Mihailovic (2, 1P) | |
| Charlotte | 0 | ||||
| 29-mar-2025 | Atlanta | Atlanta United | 4 | Miranchuk, Parks (A), Almiron, Latte Lath | |
| New York City | 3 | Wolf (2), Martinez (P) | |||
| 29-mar-2025 | Washington | DC United | 1 | Benteke | |
| Columbus | 2 | Rossi (2) | |||
| 29-mar-2025 | Fort Lauderdale | Inter | 2 | Taylor, Messi | |
| Union | 1 | Gazdag | |||
| 29-mar-2025 | Chicago | Fire | 1 | Zinckernagel | |
| Impact | 1 | Sealy | |||
| 29-mar-2025 | Frisco | Dallas | 2 | Acosta, Leo Chu | |
| Sporting | 1 | Salloi | |||
| 29-mar-2025 | Saint Paul | Minnesota United | 2 | Oluwaseyi (2) | |
| Real Salt Lake | 0 | ||||
| 29-mar-2025 | Nashville | Nashville | 1 | Bauer | |
| Cincinnati | 2 | Evander, Denkey (P) | |||
| 29-mar-2025 | Carson | Galaxy | 1 | Ramirez | |
| Orlando City | 2 | Ojeda (P), Muriel | |||
| 29-mar-2025 | San Diego | San Diego | 3 | McVey, Valakari, Mighten | |
| Los Angeles | 2 | Smoliakov, Under | |||
| 29-mar-2025 | San Jose | Earthquakes | 1 | Leroux | |
| Sounders | 1 | Rusnak | |||
| 30-mar-2025 | Saint Louis | Saint Louis City | 0 | ||
| Austin | 1 | Uzuni | |||
| 30-mar-2025 | Portland | Timbers | 3 | Mora, Antony (2) | |
| Dynamo | 1 | Escobar | |||
| 7ª Semana | |||||
| 5-abr-2025 | Charlotte | Charlotte | 2 | Zaha (P), Toklomati | |
| Nashville | 1 | Mukhtar | |||
| 5-abr-2025 | Sandy | Real Salt Lake | 2 | Luna (2) | |
| Galaxy | 0 | ||||
| 5-abr-2025 | Atlanta | Atlanta United | 1 | Almiron (P) | |
| Dallas | 1 | Musa | |||
| 5-abr-2025 | Cincinnati | Cincinnati | 1 | Sergio Santos | |
| Revolution | 0 | ||||
| 5-abr-2025 | Columbus | Crew | 2 | Jackson, Russel-Rowe | |
| Impact | 1 | Owusa | |||
| 5-abr-2025 | Harrison | Red Bulls | 2 | Ngoma, Choupo-Moting (P) | |
| Fire | 1 | Bamba | |||
| 5-abr-2025 | Chester | Union | 0 | ||
| Orlando City | 0 | ||||
| 5-abr-2025 | Austin | Austin | 0 | ||
| Timbers | 0 | ||||
| 5-abr-2025 | Kansas City | Sporting | 2 | Joveljic (2) | |
| Saint Louis City | 0 | ||||
| 5-abr-2025 | Houston | Dynamo | 1 | McGlynn | |
| Los Angeles | 0 | ||||
| 5-abr-2025 | Vancouver | Whitecaps | 2 | White, Sabbi | |
| Rapids | 0 | ||||
| 5-abr-2025 | San Diego | San Diego | 3 | Tverskov, Godoy, Lozano | |
| Sounders | 0 | ||||
| 6-abr-2025 | Bronx | New York City | 1 | Parks | |
| Minnesota United | 2 | Oluwaseyi, Trapp | |||
| 6-abr-2025 | San Jose | Earthquakes | 6 | Arango, Martinez (3), Espinoza (P), Pellegrino | |
| DC United | 1 | Benteke | |||
| 6-abr-2025 | Fort Lauderdale | Inter | 1 | Messi | |
| Toronto | 1 | Bernardeschi | |||
| 8ª Semana | |||||
| 12-abr-2025 | Toronto | Toronto | 0 | ||
| Minnesota United | 0 | ||||
| 12-abr-2025 | Atlanta | Atlanta United | 0 | ||
| Revolution | 1 | Gil (P) | |||
| 12-abr-2025 | Orlando | Orlando City | 0 | ||
| Red Bulls | 0 | ||||
| 12-abr-2025 | Washington | DC United | 0 | ||
| Cincinnati | 1 | Valenzuela | |||
| 12-abr-2025 | Montreal | Impact | 0 | ||
| Charlotte | 1 | Biel | |||
| 12-abr-2025 | Bronx | New York City | 1 | Martinez | |
| Union | 0 | ||||
| 12-abr-2025 | Vancouver | Whitecaps | 5 | White (4), Sabbi | |
| Austin | 1 | Pereira | |||
| 12-abr-2025 | Frisco | Dallas | 0 | ||
| Sounders | 1 | Musovski | |||
| 12-abr-2025 | Nashville | Nashville | 2 | Lovitz, Surridge (P) | |
| Real Salt Lake | 1 | Marczuk | |||
| 12-abr-2025 | Commerce City | Rapids | 3 | Mihailovic (P), Yapi, Navarro | |
| San Diego | 2 | De la Torre, Angel | |||
| 12-abr-2025 | Carson | Galaxy | 1 | Fagundez | |
| Dynamo | 1 | Ponce | |||
| 12-abr-2025 | Los Angeles | Los Angeles | 2 | Palencia, Bouanga | |
| Earthquakes | 1 | Espinoza | |||
| 13-abr-2025 | Kansas City | Sporting | 2 | Suleymanov, Joveljic (P) | |
| Timbers | 4 | Ayala, Kelsy (2), Miller (A) | |||
| 13-abr-2025 | Chicago | Fire | 0 | ||
| Inter | 0 | ||||
| 13-abr-2025 | Saint Louis | Saint Louis City | 1 | Joao Klauss | |
| Crew | 2 | Moreira, Rossi | |||
| 9ª Semana | |||||
| 19-abr-2025 | Austin | Austin | 1 | Vazquez | |
| Galaxy | 0 | ||||
| 19-abr-2025 | Columbus | Crew | 0 | ||
| Inter | 1 | Cremaschi | |||
| 19-abr-2025 | Charlotte | Charlotte | 3 | Abda, Agyemang (P), Privett | |
| San Diego | 0 | ||||
| 19-abr-2025 | Montreal | Impact | 0 | ||
| Orlando City | 0 | ||||
| 19-abr-2025 | Foxborough | Revolution | 2 | Campana, Ganago | |
| New York City | 0 | ||||
| 19-abr-2025 | Harrison | Red Bulls | 1 | Choupo-Moting | |
| DC United | 2 | Peglow (2) | |||
| 19-abr-2025 | Chester | Union | 3 | Sullivan, Jean Jacques, Baribo | |
| Atlanta United | 0 | ||||
| 19-abr-2025 | Seattle | Sounders | 3 | Musovski, De la Vega, Rothrock | |
| Nashville | 0 | ||||
| 19-abr-2025 | Bridgeview | Fire | 2 | Cuypers, Gutierrez (P) | |
| Cincinnati | 3 | Evander (2), Denkey | |||
| 19-abr-2025 | Houston | Dynamo | 2 | Bassi, Lingr | |
| Rapids | 2 | Mihailovic (P), Navarro | |||
| 19-abr-2025 | Saint Paul | Minnesota United | 0 | ||
| Dallas | 0 | ||||
| 19-abr-2025 | Saint Louis | Saint Louis City | 0 | ||
| Whitecaps | 0 | ||||
| 19-abr-2025 | Sandy | Real Salt Lake | 0 | ||
| Toronto | 1 | Corbeanu | |||
| 19-abr-2025 | Portland | Timbers | 3 | Mora (2, 1P), Moreno | |
| Los Angeles | 3 | Giroud, Martinez | |||
| 19-abr-2025 | San Jose | Earthquakes | 3 | Martinez, Arango (2, 1P) | |
| Sporting | 5 | Ndenbe, Salloi (2), Garcia, Thommy | |||
| 10ª Semana | |||||
| 26-abr-2025 | Cincinnati | Cincinnati | 2 | Denkey (2) | |
| Sporting | 1 | Bassong | |||
| 26-abr-2025 | Toronto | Toronto | 0 | ||
| New York City | 1 | Martinez (P) | |||
| 26-abr-2025 | Harrison | Red Bulls | 1 | Eile | |
| Impact | 0 | ||||
| 26-abr-2025 | Chester | Union | 3 | Glesnes, Jean Jacques, Damiani | |
| DC United | 0 | ||||
| 26-abr-2025 | Orlando | Orlando City | 3 | Muriel (P), Freeman, Pasalic | |
| Atlanta United | 0 | ||||
| 26-abr-2025 | Charlotte | Charlotte | 0 | ||
| Foxborough | 1 | Gil | |||
| 26-abr-2025 | Columbus | Crew | 2 | Zawadzki, Arfsten | |
| Earthquakes | 1 | Martinez | |||
| 26-abr-2025 | San Diego | San Diego | 1 | Lozano (P) | |
| Real Salt Lake | 3 | Luna (2, 1P), Junqua | |||
| 26-abr-2025 | Houston | Dynamo | 2 | Lingr, Ponce | |
| Austin | 0 | ||||
| 26-abr-2025 | Nashville | Nashville | 7 | Surridge (4, 2P), Palacios, Mukhtar (2) | |
| Fire | 2 | Zinckernagel, Cuypers | |||
| 26-abr-2025 | Commerce City | Rapids | 1 | Mihailovic | |
| Sounders | 1 | Musovski | |||
| 27-abr-2025 | Saint Paul | Minnesota United | 1 | Trapp | |
| Whitecaps | 3 | Berhalter, Vite (2) | |||
| 27-abr-2025 | Fort Lauderdale | Inter | 3 | Picault, Obando, Martinez | |
| Dallas | 4 | Moore, Urhoghide, Julio, Pedrinho | |||
| 27-abr-2025 | Los Angeles | Los Angeles | 2 | Bouanga (2) | |
| Saint Louis | 2 | Teuchert, Ordaz (A) | |||
| 27-abr-2025 | Carson | Galaxy | 2 | Ramirez, Reus | |
| Timbers | 4 | David Costa, Moreno, Kelsy, Rodriguez (P) | |||
| 11ª Semana | |||||
| 3-may-2025 | Atlanta | Atlanta United | 1 | Almiron | |
| Nashville | 1 | Lovitz | |||
| 3-may-2025 | Toronto | Toronto | 0 | ||
| Revolution | 2 | Gil, Campana | |||
| 3-may-2025 | Columbus | Crew | 4 | Chambost, Rossi (P), Jackson, Russell-Rowe | |
| Charlotte | 2 | Zaha (P), Abada | |||
| 3-may-2025 | Washington | DC United | 2 | Benteke, Kijima | |
| Rapids | 1 | Yapi | |||
| 3-may-2025 | Fort Lauderdale | Inter | 4 | Picault, Weingandt, Suarez, Messi | |
| Red Bulls | 1 | Sofo | |||
| 3-may-2025 | Montreal | Impact | 1 | Vrioni | |
| Union | 2 | Vassilev, Uhre | |||
| 3-may-2025 | Austin | Austin | 0 | ||
| Minnesota United | 3 | Sanchez (A), Markanich, Pereyra | |||
| 3-may-2025 | Chicago | Fire | 0 | ||
| Orlando City | 0 | ||||
| 3-may-2025 | San Diego | San Diego | 5 | Lozano (2, 1P), Dreyer, Valakari, Iloski | |
| Dallas | 0 | ||||
| 3-may-2025 | Vancouver | Whitecaps | 2 | Nelson, Blackmon | |
| Real Salt Lake | 1 | Luna (P) | |||
| 3-may-2025 | Los Angeles | Los Angeles | 2 | Ordaz, Ebobisse | |
| Houston | 0 | ||||
| 3-may-2025 | San Jose | Earthquakes | 4 | Espinoza (2), Arango, Bouda | |
| Timbers | 1 | Mora | |||
| 3-may-2025 | Seattle | Sounders | 4 | Rusnak (P), Vargas, Musovski, Tolo | |
| Saint Louis City | 1 | Hartel (P) | |||
| 4-may-2025 | Bronx | New York City | 1 | Fernandez | |
| Cincinnati | 0 | ||||
| 4-may-2025 | Kansas City | Sporting | 1 | Yoshida (A) | |
| Galaxy | 0 | ||||
| 12ª Semana | |||||
| 10-may-2025 | Bridgeview | Fire | 2 | Cuypers (P), Kouame | |
| Atlanta United | 1 | Rogers (A) | |||
| 10-may-2025 | Saint Paul | Minnesota United | 4 | Hlongwane, Markanich, Weigandt (A), Lod | |
| Inter | 1 | Messi | |||
| 10-may-2025 | Toronto | Timbers | 2 | Insigne, Bartlett (A) | |
| DC United | 0 | ||||
| 10-may-2025 | Cincinnati | Cincinnati | 2 | Evander, Valenzuela | |
| Austin | 1 | Vazquez (P) | |||
| 10-may-2025 | Harrison | Red Bulls | 7 | Choupo-Moting (2), Forsberg (2), Harper, Gjengaar, Yamane (A) | |
| Galaxy | 0 | ||||
| 10-may-2025 | Bronx | New York City | 0 | ||
| Impact | 1 | Owusu | |||
| 10-may-2025 | Orlando | Orlando City | 3 | Ojeda (3, 1P) | |
| Revolution | 3 | Yusuf, Polster, Gil (P) | |||
| 10-may-2025 | Chester | Union | 2 | Baribo, Westfield | |
| Crew | 2 | Arfsten, Zawadzki | |||
| 10-may-2025 | Frisco | Dallas | 1 | Julio | |
| Real Salt Lake | 1 | Luna | |||
| 10-may-2025 | Houston | Dynamo | 1 | Awodesu | |
| Sounders | 3 | Musovski, Rusnak (2) | |||
| 10-may-2025 | Nashville | Nashville | 2 | Mukhtar, Shaffelburg | |
| Charlotte | 1 | Abada | |||
| 10-may-2025 | Saint Louis | Saint Louis City | 1 | Hiebert | |
| San Diego | 2 | Iloski, Dreyer | |||
| 10-may-2025 | Commerce City | Rapids | 0 | ||
| Earthquakes | 2 | Jones, Arango | |||
| 10-may-2025 | Portland | Timbers | 1 | Moreno | |
| Sporting | 0 | ||||
| 10-may-2025 | Vancouver | Whitecaps | 2 | White | |
| Los Angeles | 2 | Delgado, Bouanga (P) | |||
| 13ª Semana | |||||
| 14-may-2025 | Washington | DC United | 0 | ||
| New York City | 0 | ||||
| 14-may-2025 | Montreal | Impact | 1 | Petrasso | |
| Crew | 1 | Russell-Rowe | |||
| 14-may-2025 | Orlando | Orlando City | 3 | Muriel, Ojeda, Enrique | |
| Charlotte | 1 | Zaha | |||
| 14-may-2025 | Chester | Union | 3 | Harriel, Baribo (2) | |
| Galaxy | 2 | Cuevas, Fagundez | |||
| 14-may-2025 | Toronto | Toronto | 0 | ||
| Cincinnati | 1 | Denkey | |||
| 14-may-2025 | Houston | Dynamo | 2 | Ortiz, Felipe Andrade | |
| Minnesota United | 0 | ||||
| 14-may-2025 | Nashville | Nashville | 2 | Yazbek, Mukhtar | |
| Red Bulls | 1 | Choupo-Moting | |||
| 14-may-2025 | Saint Louis | Saint Louis City | 2 | Pompeu, Teuchert | |
| Sporting | 2 | Leibold, Joveljic | |||
| 14-may-2025 | Austin | Austin | 1 | Vazquez | |
| Atlanta United | 1 | Thiare | |||
| 14-may-2025 | Sandy | Real Salt Lake | 0 | ||
| Timbers | 0 | ||||
| 14-may-2025 | Los Angeles | Los Angeles | 4 | Under, Ebobisse, Bouanga, Yeboah | |
| Sounders | 0 | ||||
| 14-may-2025 | San Diego | San Diego | 2 | McVey, Dreyer | |
| Rapids | 0 | ||||
| 14-may-2025 | San Jose | Earthquakes | 3 | Arango, Leroux, Harkes | |
| Inter | 3 | Falcon, Allende (2) | |||
| 17-may-2025 | Montreal | Impact | 1 | Vrioni | |
| Toronto | 6 | Spicer, Bernardeschi (2), Brynhildsen, Corbeanu (2) | |||
| 17-may-2025 | Bronx | New York City | 2 | Martinez, Moralez | |
| Red Bulls | 0 | ||||
| 17-may-2025 | Columbus | Crew | 1 | Rossi (P) | |
| Cincinnati | 1 | Denkey | |||
| 17-may-2025 | Atlanta | Atlanta United | 0 | ||
| Union | 1 | Baribo (P) | |||
| 17-may-2025 | Charlotte | Charlotte | 1 | Agyemang | |
| Fire | 4 | Bamba, Gutierrez (2), Zinckernagel | |||
| 17-may-2025 | Foxborough | Revolution | 0 | ||
| Earthquakes | 0 | ||||
| 17-may-2025 | Austin | Austin | 0 | ||
| Whitecaps | 0 | ||||
| 17-may-2025 | Saint Paul | Minnesota United | 3 | Oluwaseyi, Pereyra, Gressel | |
| Saint Louis City | 0 | ||||
| 17-may-2025 | Nashville | Nashville | 0 | ||
| DC United | 0 | ||||
| 17-may-2025 | Frisco | Dallas | 0 | ||
| Dynamo | 2 | McGlynn, Dorsey | |||
| 17-may-2025 | Commerce City | Rapids | 1 | Mihailovic | |
| Real Salt Lake | 0 | ||||
| 17-may-2025 | Portland | Timbers | 1 | Moreno | |
| Sounders | 1 | Rusnak | |||
| 17-may-2025 | San Diego | San Diego | 0 | ||
| Sporting | 0 | ||||
| 18-may-2025 | Fort Lauderdale | Inter | 0 | ||
| Orlando City | 3 | Muriel, Pasalic, Thorshallsson | |||
| 18-may-2025 | Carson | Galaxy | 2 | Reus (2) | |
| Los Angeles | 2 | Bouanga, Ordaz | |||
| 14ª Semana | |||||
| 24-may-2025 | Seattle | Sounders | 1 | Rusnak (P) | |
| Dallas | 0 | ||||
| 24-may-2025 | San Diego | San Diego | 2 | De la Torre, Lozano | |
| Galaxy | 1 | Fagundez | |||
| 24-may-2025 | Charlotte | Charlotte | 3 | Agyemang (2), Biel | |
| Crew | 2 | Aliyu, Amundsen | |||
| 24-may-2025 | Washington | DC United | 0 | ||
| Red Bulls | 2 | Harper, Sofo | |||
| 24-may-2025 | Montreal | Impact | 2 | Vrioni, Owusu (P) | |
| Los Angeles | 2 | Delgado, Giroud | |||
| 24-may-2025 | Orlando | Orlando City | 1 | McGuire | |
| Timbers | 0 | ||||
| 24-may-2025 | Chester | Union | 3 | Sullivan, Baribo (2) | |
| Inter | 3 | Allende, Messi, Segovia | |||
| 24-may-2025 | Toronto | Toronto | 1 | Osorio | |
| Nashville | 2 | Surridge (2) | |||
| 24-may-2025 | Kansas City | Sporting | 3 | Salloi, Joveljic (P), Garcia | |
| Revolution | 3 | Chancalay, Bartlett (A), Urruti | |||
| 24-may-2025 | Saint Paul | Minnesota United | 1 | Boxall | |
| Austin | 1 | Kolmanic | |||
| 24-may-2025 | Commerce City | Rapids | 1 | Yapi | |
| Saint Louis City | 0 | ||||
| 24-may-2025 | Sandy | Real Salt Lake | 2 | Gozo, Luna | |
| Whitecaps | 3 | White (2, 1P), Vite | |||
| 24-may-2025 | San Jose | Earthquakes | 3 | Judd (2), Munie | |
| Dynamo | 3 | Ponce, Andrade, Dorsey | |||
| 25-may-2025 | Bronx | New York City | 3 | Bakrar, Wolf, Martinez (P) | |
| Fire | 1 | Zinckernagel | |||
| 25-may-2025 | Atlanta | Atlanta United | 4 | Williams, Fortune, Slisz, Thiare | |
| Cincinnati | 2 | Robinson, Valenzuela | |||
| 15ª Semana | |||||
| 28-may-2025 | Atlanta | Atlanta United | 3 | Miranchuk, Slisz, Thiare | |
| Orlando City | 2 | Araujo, Enrique | |||
| 28-may-2025 | Cincinnati | Cincinnati | 3 | Bucha, Denkey (P), Valenzuela | |
| Dallas | 3 | Musa, Julio, Ibeagha | |||
| 28-may-2025 | Washington | DC United | 1 | Gabriel Pirani | |
| Revolution | 1 | Feingold | |||
| 28-may-2025 | Fort Lauderdale | Inter | 4 | Messi (2), Suarez (2) | |
| Impact | 2 | Sealy, Loturi | |||
| 28-may-2025 | Harrison | Red Bulls | 4 | Bogacz, Sofo, Choupo-Moting (2P) | |
| Charlotte | 2 | Vargas, Abada | |||
| 28-may-2025 | Bronx | New York City | 0 | ||
| Dynamo | 3 | Haak (A), Segal (2, 1P) | |||
| 28-may-2025 | Toronto | Toronto | 1 | Brynhildsen | |
| Union | 2 | Harriel, Wagner | |||
| 28-may-2025 | Columbus | Crew | 2 | Rossi, Palacios (A) | |
| Nashville | 2 | Surridge, Mukhtar | |||
| 28-may-2025 | Seattle | Sounders | 1 | Ferreira | |
| San Diego | 0 | ||||
| 28-may-2025 | Austin | Austin | 1 | Rubio | |
| Real Salt Lake | 1 | Agada | |||
| 28-may-2025 | Carson | Galaxy | 0 | ||
| Earthquakes | 1 | Bouda | |||
| 28-may-2025 | Portland | Timbers | 2 | Antony, Kelsy | |
| Rapids | 1 | Mihailovic | |||
| 28-may-2025 | Vancouver | Whitecaps | 0 | ||
| Minnesota United | 0 | ||||
| 31-may-2025 | Saint Louis | Saint Louis City | 2 | Joao Klauss, Lowen (P) | |
| Earthquakes | 1 | Martinez | |||
| 31-may-2025 | Nashville | Nashville | 2 | Surridge (2) | |
| New York City | 2 | Wolf (2) | |||
| 31-may-2025 | Cincinnati | Cincinnati | 1 | Denkey | |
| DC United | 2 | Gabriel Pirani, Antley | |||
| 31-may-2025 | Fort Lauderdale | Inter | 5 | Allende, Messi (2), Suarez, Picault | |
| Crew | 1 | Ruvalcaba | |||
| 31-may-2025 | Montreal | Impact | 0 | ||
| Revolution | 3 | Miller, Feingold (2) | |||
| 31-may-2025 | Harrison | Red Bulls | 2 | Harper, Choupo-Moting | |
| Atlanta United | 0 | ||||
| 31-may-2025 | Orlando | Orlando City | 1 | Freeman | |
| Fire | 3 | Zinckernagel, Cuypers (2) | |||
| 31-may-2025 | Toronto | Toronto | 0 | ||
| Charlotte | 2 | Biel, Abyemang | |||
| 31-may-2025 | Frisco | Dallas | 0 | ||
| Union | 0 | ||||
| 31-may-2025 | Houston | Dynamo | 1 | Kowalczyk | |
| Sporting | 3 | Joveljic (2), Muñoz | |||
| 31-may-2025 | Carson | Galaxy | 2 | Sanabria, Paintsil | |
| Real Salt Lake | 0 | ||||
| 31-may-2025 | San Diego | San Diego | 2 | De la Torre, Iloski | |
| Austin | 0 | ||||
| 1-jun-2025 | Seattle | Sounders | 2 | Kossa-Rienzi, Romero (A) | |
| Minnesota United | 3 | Oluwaseyi (2), Lod (P) | |||
| 16ª Semana | |||||
| 7-jun-2025 | Washington | DC United | 1 | Badji | |
| Fire | 7 | Haile-Selassie, Bamba, Barlow (3), Zinckernagel, Gutierrez | |||
| 7-jun-2025 | Commerce City | Rapids | 0 | ||
| Austin | 2 | Desler, Navarro | |||
| 8-jun-2025 | Portland | Timbers | 2 | Antony, Ayala | |
| Saint Louis City | 1 | Watts | |||
| 8-jun-2025 | Vancouver | Whitecaps | 3 | Badwal, Rios, Kreilach | |
| Sounders | 0 | ||||
| 8-jun-2025 | Los Angeles | Los Angeles | 3 | Segura, Bouanga, Giroud | |
| Sporting | 1 | ||||
| 17ª Semana | |||||
| 12-jun-2025 | Bronx | New York City | 4 | Moralez, Bakrar, Wolf (2) | |
| Atlanta United | 0 | ||||
| 13-jun-2025 | Portland | Timbers | 1 | Mosquera | |
| Earthquakes | 1 | Judd | |||
| 14-jun-2025 | Saint Louis | Saint Louis City | 3 | Joao Klauss (3) | |
| Galaxy | 3 | Gabriel Pec (2), Matheus Nascimento | |||
| 14-jun-2025 | Columbus | Crew | 2 | Aliya, Rossi | |
| Whitecaps | 1 | Ngando | |||
| 14-jun-2025 | Foxborough | Revolution | 0 | ||
| Cincinnati | 1 | Denkey | |||
| 14-jun-2025 | Chester | Union | 2 | Bueno, Anderson | |
| Charlotte | 1 | Zaha | |||
| 14-jun-2025 | Austin | Austin | 2 | Guilherme Biro, Vazquez | |
| Red Bulls | 1 | Vazquez (A) | |||
| 14-jun-2025 | Chicago | Fire | 0 | ||
| Nashcille | 2 | Mukhtar, Surridge | |||
| 14-jun-2025 | Houston | Dynamo | 1 | Lingr | |
| Montreal | 3 | Owusu (2), Neal | |||
| 14-jun-2025 | Saint Paul | Minnesota United | 2 | McVey, Yeboah | |
| San Diego | 4 | Dreyer (2), Iloski (2) | |||
| 14-jun-2025 | Kansas City | Sporting | 2 | Suleymanov, Muñoz | |
| Dallas | 4 | Musa, Acosta (2), Kamungo | |||
| 14-jun-2025 | Commerce City | Rapids | 0 | ||
| Orlando | 1 | Ojeda | |||
| 14-jun-2025 | Sandy | Real Salt Lake | 2 | Russell, Gozo | |
| DC United | 0 | ||||
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