| Fase Preliminar | ||||||
| 16/8/80 | Budapest | Honved | 8 | Bodonyi, Garaba, Estehazy, Kocsis (P), Dajka (2), Varga (2) | ||
| Valletta | 0 | |||||
| 3/9/80 | Ta'Qali | Valletta | 0 | |||
| Honved | 3 | Esterhazy (2), Bodonyi | ||||
| 1º Fase | ||||||
| 16/9/80 | Haarlem | Linfield | 0 | |||
| Nantes | 1 | Amisse | ||||
| 1/10/80 | Nantes | Nantes | 2 | Rampillon, Tossero | ||
| Linfield | 0 | |||||
| 17/9/80 | Aberdeen | Aberdeen | 1 | McGee | ||
| Austria | 0 | |||||
| 1/10/80 | Viena | Austria | 0 | |||
| Aberdeen | 0 | |||||
| 17/9/80 | Brujas | Brujas | 0 | |||
| Basilea | 1 | Maissen | ||||
| 1/10/80 | Basilea | Basilea | 4 | Tanner, Stonier (P), Von Wartburg, Geisser | ||
| Brujas | 1 | Ceulemans | ||||
| 17/9/80 | Sofia | CSKA Sofia | 1 | Yonchev | ||
| Nottingham Forest | 0 | |||||
| 1/10/80 | Nottingham | Nottingham Forest | 0 | |||
| CSKA Sofia | 1 | Kerimov | ||||
| 17/9/80 | Tirana | Dinamo Tirana | 0 | |||
| Ajax | 2 | Arnesen (2) | ||||
| 01/10/1980 | Amsterdam | Ajax | 1 | Lerby (P) | ||
| Dinamo Tirana | 0 | |||||
| 17/9/80 | Berlin | Dinamo Berlin | 3 | Terletzki, Trieloff, Schultz | ||
| Apoel | 0 | |||||
| 1/10/80 | Levkosia | Apoel | 2 | Haitis, Petrov | ||
| Dinamo Berlin | 1 | Seier | ||||
| 17/9/80 | Halmstad | Halmstads | 0 | |||
| Esbjerg | 0 | |||||
| 1/10/80 | Esbjerg | Esbjerg | 3 | Iversen, Lauridsen, Nielsen | ||
| Halmstads | 2 | Johansson, Larsson | ||||
| 17/9/80 | Vestmannaeyjar | IBV | 1 | Þorleifsson | ||
| Banik | 1 | Danek | ||||
| 1/10/80 | Ostrava | Banik | 1 | Vojacek | ||
| IBV | 0 | |||||
| 17/9/80 | Milan | Internazionale | 2 | Altobelli (2, 1P) | ||
| Universitatea Craiova | 0 | |||||
| 1/10/80 | Craiova | Universitatea Craiova | 1 | Beldeanu | ||
| Internazionale | 1 | Muraro | ||||
| 17/9/80 | Esch-sur-Alzette | Jeunesse | 0 | |||
| Spartak | 5 | Gavrilov (2), Khidijatullin, Rodionov, Yartsev | ||||
| 01/10/1980 | Moscu | Spartak | 4 | Pigot (A), Rodionov, Gavrilov, Yartsev | ||
| Jeunesse | 0 | |||||
| 17/9/80 | Dublin | Limerick United | 1 | Kennedy | ||
| Real Madrid | 2 | Juanito (P), Pineda | ||||
| 1/10/80 | Madrid | Real Madrid | 5 | Santillana, Juanito, Angel, Cunningham, Pineda | ||
| Limerick United | 1 | Kennedy | ||||
| 17/9/80 | El Pireo | Olympiakos | 2 | Galakos, Ardizoglu | ||
| Bayern Munich | 4 | Dremmler (2), Rummenigge, Kraus | ||||
| 1/10/80 | Munich | Bayern Munich | 3 | Hoeneß, Rummenigge, Janzon (P) | ||
| Olympiakos | 0 | |||||
| 17/9/80 | Oulu | OPS | 1 | Puotiniemi | ||
| Liverpool | 1 | McDermott | ||||
| 1/10/80 | Liverpool | Liverpool | 10 | Souness (3), McDermott (3), Lee, Kennedy, Fairclough (2) | ||
| OPS | 1 | Armstrong (A) | ||||
| 17/9/80 | Lisboa | Sporting | 0 | |||
| Honved | 2 | Bodonyi, Nagy | ||||
| 1/10/80 | Budapest | Honved | 1 | Dajka | ||
| Sporting | 0 | |||||
| 17/9/80 | Trabzon | Trabzonspor | 2 | Sinan, Tuncay | ||
| Szombierki | 1 | Wieczorek | ||||
| 1/10/80 | Bytom | Szombierki | 3 | Bys, Ogaza, Sroka (P) | ||
| Trabzonspor | 0 | |||||
| 17/9/80 | Stavanger | Viking | 2 | Svendsen, Saboe | ||
| Estrella Roja | 3 | Petrovic, Brekke (A), Repcic | ||||
| 1/10/80 | Belgrado | Estrella Roja | 4 | Durovski, Janjanin, Petrovic, Stamenkovic | ||
| Viking | 1 | Brekke | ||||
| 2º Ronda | ||||||
| 22/10/80 | Madrid | Real Madrid | 1 | Santillana | ||
| Honved | 0 | |||||
| 4/11/80 | Budapest | Honved | 0 | |||
| Real Madrid | 2 | Cunningham, Garcia Hernandez | ||||
| 22/10/80 | Aberdeen | Aberdeen | 0 | |||
| Liverpool | 1 | McDermott | ||||
| 5/11/80 | Liverpool | Liverpool | 4 | Miller (A), Neal, Dalglish, Hansen | ||
| Aberdeen | 0 | |||||
| 22/10/80 | Ostrava | Banik | 0 | |||
| Dinamo Berlin | 0 | |||||
| 5/11/80 | Berlin | Dinamo Berlin | 1 | Troppa (A) | ||
| Banik | 1 | Knapp (P) | ||||
| 22/10/80 | Basilea | Basilea | 1 | Lauscher | ||
| Estrella Roja | 0 | |||||
| 5/11/80 | Belgrado | Estrella Roja | 2 | Repcic, Janjanin | ||
| Basilea | 0 | |||||
| 22/10/80 | Munich | Bayern Munich | 5 | Durnberger, Rummenigge (2), Hoeneß (2) | ||
| Ajax | 1 | Arnesen | ||||
| 05/11/1980 | Amsterdam | Ajax | 2 | Wiggemansen, Rijkaard | ||
| Bayern Munich | 1 | Rummenigge | ||||
| 22/10/80 | Sofia | CSKA Sofia | 4 | Yonchev (3), Zdravkov | ||
| Szombierki | 0 | |||||
| 5/11/80 | Chorzow | Szombierki | 0 | |||
| CSKA Sofia | 1 | Dzhevizov | ||||
| 22/10/80 | Nantes | Nantes | 1 | Rio (P) | ||
| Internazionale | 2 | Altobelli, Prohaska | ||||
| 05/11/1980 | Milan | Internazionale | 1 | Altobelli | ||
| Nantes | 1 | Amisse | ||||
| 22/10/80 | Moscu | Spartak | 3 | Khidijatullin (2), Shavlo | ||
| Esbjerg | 0 | |||||
| 5/11/80 | Esbjerg | Esbjerg | 2 | Lauridsen, Iversen | ||
| Spartak | 0 | |||||
| 4º Final | ||||||
| 4/3/81 | Munich | Bayern Munich | 2 | Janzon, Breitner (P) | ||
| Banik | 0 | |||||
| 18/3/81 | Ostrava | Banik | 2 | Nemec, Licka | ||
| Bayern Munich | 4 | Hoeneß, Kraus (2), Durnberger | ||||
| 4/3/81 | Milan | Internazionale | 1 | Caso | ||
| Estrella Roja | 1 | Repcic | ||||
| 18/3/81 | Belgrado | Estrella Roja | 0 | |||
| Internazionale | 1 | Muraro | ||||
| 4/3/81 | Liverpool | Liverpool | 5 | Souness (3), Lee, McDermott | ||
| CSKA Sofia | 1 | Yonchev | ||||
| 18/03/1981 | Sofia | CSKA Sofia | 0 | |||
| Liverpool | 1 | Johnson | ||||
| 4/3/81 | Tbilisi | Spartak | 0 | |||
| Real Madrid | 0 | |||||
| 19/3/81 | Madrid | Real Madrid | 2 | Isidro (2) | ||
| Spartak | 0 | |||||
| SEMIFINALES | ||||||
| 8/4/81 | Liverpool | Liverpool | 0 | |||
| Bayern Munich | 0 | |||||
| 22/4/81 | Munich | Bayern Munich | 1 | Rummenigge | ||
| Liverpool | 1 | Kennedy | ||||
| 8/4/81 | Madrid | Real Madrid | 2 | Santillana, Juanito | ||
| Internazionale | 0 | |||||
| 22/4/81 | Milan | Internazionale | 1 | Bini | ||
| Real Madrid | 0 | |||||
| FINAL | ||||||
| 27/5/81 | Paris | Liverpool | 1 | Kennedy | ||
| Real Madrid | 0 | |||||
| Campeón: LIVERPOOL (INGLATERRA) | ||||||